Cardiorenal Anemia Syndrome (CRAS) involves the complex interplay of heart failure, chronic kidney disease, and anemia. Over 40% of heart failure patients experience CRAS, complicating their management. Anemia worsens both heart failure and chronic kidney disease, with inflammation and hepcidin playing key roles in iron deficiency. Addressing iron deficiency is crucial for improving patient outcomes and understanding the relationships among these conditions.